Treatment of Recurrent Childhood Kidney Tumors

For information about the treatments listed below, see the Treatment Option Overview section.

Treatment of recurrent Wilms tumor may include:

• Combination chemotherapy, surgery, and radiation therapy.
• Combination chemotherapy and radiation therapy, followed by stem cell rescue, using the child's own blood stem cells.
• A clinical trial that checks a sample of the patient's tumor for certain gene changes. The type of targeted therapy that will be given to the patient depends on the type of gene change.
• A clinical trial of combination chemotherapy for patients with relapsed favorable histology Wilms tumor.

Treatment of recurrent rhabdoid tumor of the kidney may include:

• A clinical trial that checks a sample of the patient's tumor for certain gene changes. The type of targeted therapy that will be given to the patient depends on the type of gene change.

Treatment of recurrent clear cell sarcoma of the kidney may include:

• Combination chemotherapy, surgery to remove the tumor (if possible), with or without radiation therapy.
• A clinical trial that checks a sample of the patient's tumor for certain gene changes. The type of targeted therapy that will be given to the patient depends on the type of gene change.

Treatment of recurrent congenital mesoblastic nephroma may include:

• Combination of chemotherapy, surgery, and radiation therapy.
• Targeted therapy such as larotrectinib or entrectinib.
• A clinical trial that checks a sample of the patient's tumor for certain gene changes. The type of targeted therapy that will be given to the patient depends on the type of gene change.
• A clinical trial of targeted therapy (LOXO-101 or entrectinib).

Treatment of other recurrent childhood kidney tumors is usually within a clinical trial.

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.